09041nam#a2200553#i#4500001000500000005001700005008004000022020002300062041000900085044000900094072002400103100013900127100015700266100013600423100016900559100015900728245018700887260003901074300001201113500169901125510022402824510018703048510021603235510020803451510022703659510021303886510022404099510019604323510026204519510023504781510021805016510022505234510026205459510018105721510020705902510026806109510017306377510019706550510023406747510016206981510019407143510022807337510019507565510018307760510024307943510024208186533003308428856002608461239020241121142717.4  20220211d2022####ek#y0engy0150####ca##$a978-1-922756-08-40#$aENG##$axxu#7$aGeneral. TEC000000#1$aChistyakova, Guzel Nukhovna$aInstitution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia#1$aUstyantseva, Lyudmila Stanislavovna$aBudgetary Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia#1$aRemizova, Irina Ivanovna$aInstitution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia#1$aRyumin, Vladislav Evgenievich$athe Federal State Budgetary Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia#1$aBychkova, Svetlana Vladimirovna$aState Budgetary Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia00$aCHILDREN WITH EXTREMELY LOW BODY WEIGHT: CLINICAL CHARACTERISTICS, FUNCTIONAL STATE OF THE IMMUNE SYSTEM, PATHOGENETIC MECHANISMS OF THE FORMATION OF NEONATAL PATHOLOGY$cMonography1#$aMelbourne$bAUS PUBLISHERS$c2022##$a132 p.##$aThe purpose of the monograph, which contains a modern view of the problem of adaptation of
children with extremely low body weight, is to provide a wide range of doctors with basic information
about the clinical picture, functional activity of innate and adaptive immunity, prognostic criteria
of postnatal pathology, based on their own research. The specific features of the immunological
reactivity of premature infants of various gestational ages who have developed bronchopulmonary
dysplasia (BPD) and retinopathy of newborns (RN) from the moment of birth and after reaching
postconceptional age (37-40 weeks) are described separately. The mechanisms of their implementation
with the participation of factors of innate and adaptive immunity are considered in detail. Methods
for early prediction of BPD and RN with the determination of an integral indicator and an algorithm
for the management of premature infants with a high risk of postnatal complications at the stage
of early rehabilitation are proposed. The information provided makes it possible to personify the
treatment, preventive and rehabilitation measures in premature babies. The monograph is intended for
obstetricians-gynecologists, neonatologists, pediatricians, allergists-immunologists, doctors of other
specialties, residents, students of the system of continuing medical education.
This work was done with financial support from the Ministry of Education and Science, grant of
the President of the Russian Federation No. MK-1140.2020.7.$aChildren, extremely low body mass, neonatal pathology, immune system, weight, immunity, postnatal pathology, newborns$a10.26526/monography_62061e70cc4ed1.466110160#$aAilamazyan E. K. Controversial problems of premature birth and nursing children with extremely low weight / E. K. Ailamazyan, I. I. Evsyukova // Journal of obstetrics and women's diseases. - 2011. - No. 3. - P.183-189.0#$aAlbitsky V.Yu. Neonatal Mortality with Extreme Low Birth Weight  /Albitsky V.Yu., E.N. Baybarina, Z.Kh. Sorokin et al. // Public health and health care. - 2010. - No. 2. - P. 16-21.0#$aBaybarina E.N. Outcomes of pregnancy in the period of 22-27 weeks in medical institutions of the Russian Federation / E. N.Baybarina, Z. Kh. Sorokina // Issues of modern pediatrics. - 2011. - No. 1. - P. 17-20.0#$aBashmakova N. V., Bashmakova N. V., Kovalev V. V., Litvinova A. M. et al. Survival rate and current perinatal technologies for nursing newborns with extremely low body weight. - 2012. - No. 1. - P. 4-7.0#$aSimmons, L.E. Preventing preterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions / L.E.Simmons, C.E.Rubens, G.L. Darmstadt et al. // Semin Perinatol. -2010. - Vol.34, № 6. -R.408-415.0#$aLatini, G. Survival rate and prevalence of bronchopulmonary dysplasia in extremely low birth weight infants / G.Latini, C.De Felice, R. Giannuzzi et al. // Early Hum. Dev. -2013. -Vol. 89, № 1. - R. 69-73.0#$aVinogradova I. V. The state of health of children with extremely low body weight at birth and in long-term / I.V. Vinogradova, M. V. Krasnov // Bulletin of modern clinical medicine. - 2013. - V. 6. - No. 1. - P. 20-25.0#$aFellman, V. One-year survival of extremely preterm infants after active perinatal care in Sweden / V.Fellman, L.Hellström-Westas, M.Norman // JAMA. -2009. -Vol. 301, № 21. - R. 2225-2233.0#$aValiulina A. Ya. Problems and prospects of successful nursing and rehabilitation of children born with low and extremely low body weight / A.Ya. Valiulina, E.N. Akhmadeeva, N.N. Kryvkina // Bulletin of modern clinical medicine. - 2013. - No. 6. - P. 34-41.0#$aMoore, G.P. Neurodevelopmental outcomes at 4 to 8 years of children born at 22 to 25 weeks’ gestational age. A Meta-analysis / G.P.Moore, B.Lemyre, N.Barrowman et al. // JAMA Pediatrics. -2013. - Vol. 167, № 10. - R. 967-974.0#$aOrcesi, S. Neurodevelopmental outcomes of preterm very low birth weight infants born from 2005 to 2007 / S.Orcesi, I.Olivieri, S.Longo et al. // Eur. J. Paediatr. Neurol. – 2012. - Vol. 16, № 6. - P. 716-723.0#$aBashmakova N. V. Monitoring of children born with extremely low body weight in the perinatal center / N. V. Bashmakova, A. M. Litvinova, G.B. Malgina and others // Obstetrics and gynecology. - 2015. - No. 9. - P. 80-86.0#$aAntonov A. G. Intensive therapy and principles of nursing children with extremely low birth weight: methodological letter / A. G. Antonov, O. A. Borisevich, A. S. Burkov et al. - M.: Research Center of Obstetrics, Gynecology and Perinatology, 2011. - 70 p.0#$aManagement of children born with extremely low body weight (ELBW): a clinical review of international data // Family health: inf. - educ. bullet. - 2011. - No. 2. - P. 2 - 24.0#$aMerzlova N.B. Catamnesis of children born with very low and extremely low body weight / N. B. Merzlova, Yu. V. Kurnosova, L. N. Vinokurova et al. // Fundamental research. - 2013. - No. 3. - P. 121-125.0#$aBirenbaum, H.J. Reduction in the incidence of chronic lung disease in very low birth weight infant’s results of a quality improvement process in a testiary level neonatal intensive care unit / H.J.Birenbaum // Pediatrics. - 2009. - Vol. 123, № 1. - P. 44-50.0#$aStephanie D. V. Clinical immunology and immunopathology of childhood: a guide for doctors / D. V. Stephanie, Yu. E. Veltischev. – M.: Medicine, 1996. – P. 125-166.0#$aCaron, J.E. Multiplex analysis of toll-like receptor-stimulated neonatal cytokine response /J.E.Caron, T.R.La Pine, N.H.Augustine et al.// Neonatology. - 2010. - Vol. 97, № 3. - P. 266-273.0#$aKapitanović Vidak, H. The association between proinflammatory cytokine polymorphisms and cerebral palsy in very preterm infants / H. Kapitanović Vidak, T.Catela Ivković, M.Jokić // Cytokine. -2012. -Vol. 58, №1. - P.57-64.0#$aMatsuda, Y. T-cell activation in abnormal perinatal events / Y.Matsuda, H.Kato, K.Imanishi et al.// Microbiol Immunol. - 2010. - Vol. 54, № 1. - P. 38-45.0#$aGromada N. E. Diagnostic value of cytokines in newborns with serious hypoxic injuries of the central nervous system / N.Ye. Gromada // Ural Medical Journal. - 2008. - No. 12. - P. 140-145.0#$aGille, S. Clearance of apoptotic neutrophils is diminished in cord blood monocytes and does not lead to reduced IL-8 production / S.Gille, F.Steffen, K. Lauber et al. // Pediatr. Res. -2009. - Vol. 66, № 5. - R. 507-512.0#$aCharipova B.T. Clinical characteristics of children with extremely low birth weight / B.T. Charipova, G.N. Chistyakova, M. N.Tarasova // Ural Medical Journal. - 2010. - No. 5. - P. 147-151.0#$aLuciano, A.A. Alterations in regulatory T cell subpopulations seen in preterm infants /A.A.Luciano, I.M.Arbona-Ramirez, R.Ruiz // PLoS One. - 2014. -Vol.9, № 5. - P.958 - 967.0#$aG.S. Koval Features of the immunity of deeply premature newborns in infectious and inflammatory diseases / G.S. Koval, S. A. Samsygin, L. K. Kuznetsova // Russian Bulletin of Perinatology and Pediatrics. – 1999. - No. 2. – P. 8 - 11.0#$aPertseva V.A. Characteristics of humoral immunity of premature newborns, depending on the characteristics of the course of the neonatal period / V. A. Pertseva, N. I. Zakharova // Russian medical journal. - 2011. - No. 31. - P. 11 - 15.##$aThere is an electronic copy4#$aauspublishers.com.au